Compositional safety of event DAS-40278-9 (AAD-1) herbicide-tolerant maize

Herman RA, et al (2010). GM Crops 1:5, 1-18.

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This paper is relevant to the Agronomic, and Safety & Health Impact categories in the following areas:

Crops:Maize
Traits:Herbicide Tolerance
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ImpactAreas:Agronomic, and Safety & Health

Abstract or Summary:

Event DAS-40278-9 maize expresses the aryloxyalkanoate dioxygenase-1 enzyme, which was originally identified in the soil bacterium Sphingobium herbicidovorans. This enzyme degrades 2,4-dichlorophenoxyacetic acid (2,4-D) and aryloxyphenoxypropionate herbicides (e.g., haloxyfop, cyhalofop, quizalofop, etc.); therefore, plants that contain this enzyme are tolerant to these herbicides.  We employed the substantial equivalence approach to investigate the compositional safety of event DAS-40278-9 maize.  A total of 82 different compositional analyses were conducted to evaluate the equivalence of event DAS-40278-9 and conventional maize.  Analyte levels within the transgenic entries were either within literature ranges for non-transgenic maize or statistically indistinguishable from the non-transgenic near-isogenic hybrid, thus indicating substantial equivalence between event DAS-40278-9 and its conventional counterpart.  These results agree with dozens of published studies for other transgenic events where input traits were found to have a negligible effect on crop composition compared with traditional breeding methods.

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